Dravet Syndrome is an intractable form of childhood epilepsy associated with deleterious mutations in SCN1A, the gene encoding neuronal sodium channel Nav1.1.Earlier studies using human induced pluripotent stem cells (iPSCs) have produced mixed results regarding the importance of Nav1.1 in human inhibitory versus excitatory neurons.We studied a Nav
Prader-Willi syndrome in the newborn is essentially characterized by marked hypotonia, feeding difficulties, hypogonadism, Cardio-Pulmonary Monitors - ECG Mounts and possible characteristic facial features.However, diagnosis at this age may be particularly difficult, and dysmorphic features may be subtle or absent.Prematurity Dice can furthermore d
Groundwater is under pressure from a changing climate and increasing anthropogenic demands.In this study, we project the effect of these two processes onto future groundwater status.Climate projections of Representative Concentration Pathway 4.5 (RCP4.5) and Representative Concentration Pathway 8.5 (RCP8.5) from the Coupled Model Intercomparison Pr
Abstract Tuberculous meningitis (TBM) is the most lethal form of tuberculosis.Clinical features, such as coma, can predict death, but they are insufficient for the accurate prognosis of other outcomes, especially when impacted by co-morbidities such as HIV infection.Brain magnetic resonance imaging (MRI) characterises the extent and severity of dis
The urban heat island is generally conducted based on ground observations of air temperature and remotely sensing of land surface temperature (LST).Satellite remotely sensed LST has the advantages of global coverage and consistent periodicity, which overcomes the weakness of ground observations related to sparse distributions and costs.For human re